This fellowship opportunity will provide an intensive clinical and basic research experience for a urologist who has completed his training and desires to develop a specialized interest in minimally invasive techniques in urinary calculus disease, metabolic evaluation and management of nephrolithiasis, endourology, laparoscopy, and BPH.  The fellow will devote approximately 60% of his time to research and 40% to clinical responsibilities.  The duration of this fellowship is two years.  Although the breadth of the research experience is extensive, it is anticipated that each fellow will submit a specified research project for consideration for funding as a fellow through the AUA Foundation (the research proposal will be developed and written here but in consultation with the proposed fellow and will be based on aspects of one of our NIH grants).

Research Responsibilities

1. Innumerable clinical projects derived from our extensive database on urolithiasis, laparoscopy, and BPH patients.  The large volume of cases provides a wealth of clinical material.  Clinical projects are often done in conjunction with residents during their research rotations. 
2. Basic science and animal laboratory projects.  Our basic science laboratory is a collaborative one with the Department of Anatomy at the Indiana University School of Medicine.  We currently hold two NIH PO1 (program project) grants and an RO1 in the areas of shock wave lithotripsy and the pathogenesis of nephrolithiasis.  Most of our grants are multi-institutional in nature.  Collaborating institutions include the Applied Physics Laboratory at the University of Washington, the Graduate Aeronautical Laboratories at CalTech, the department of nephrology at the University of Chicago, the Department of Aerospace and Mechanical Engineering at Boston University, and the Department of Acoustics at Moscow State University, Moscow, Russia.  The fellow will have an office on the Methodist campus in close proximity to the animal lab and also in our basic science lab at the Indiana University School of Medicine.  Animal studies focus on ESWL, percutaneous, and laparoscopic techniques.

Clinical Responsibilities

1. The fellow will participate in daily ward rounds and will help oversee the clinical care of the patients he has operated on, as well as any other stone patients in the hospital.  Primary responsibility for patient care falls to the urology residents.  He will be under the direct supervision of James E. Lingeman, M.D. and Larry C. Munch, M.D.
2. The fellow will have the opportunity to become facile in the use of the shock wave lithotripsy system (Dornier HM3).
3. The fellow will have the opportunity to participate in numerous and varied endourologic and minimally invasive procedures including percutaneous nephrostolithotomy, percutaneous endopyelotomy, ureteroscopy, laparoscopic procedures, Holmium laser prostatectomy (HoLEP), etc., utilizing the latest technology available in this field.
4. The fellow will see patients in the clinic with Dr. Lingeman or Dr. Munch one ½ day per week.

Application Process
Applicants must complete an accredited urology residency in the U.S. before joining the fellowship.  This fellowship participates in the Endourological Society fellowship match program.  Details and application forms are available at http://www.endourology.org/fellowship/.

Previous Fellows and their Current Institution:

Recent Publications from Our Group:

1. Evan AP, Lingeman JE, Coe FL, Parks JH, Bledsoe SB, Shao Y, Sommer AJ, Paterson RF, Kuo RL, and Grynpas M.  Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle.  The Journal of Clinical Investigation 111(5):607-616, March 2003
2. Lingeman JE, Preminger GM, Berger Y, Denstedt JD, Goldstone L, Segura JW, Auge BK, Watterson JD, and Kuo RL.  Use of a temporary ureteral drainage stent (TUDS) after uncomplicated ureteroscopy:  results from a phase II clinical trial.  J Urol 169:1682-1688, May 2003
3. Williams JC Jr, Saw KC, Paterson RF, Hatt EK, McAteer JA, and Lingeman JE.  Variability of renal stone fragility in shock wave lithotripsy.  Urology 61(6):1092-1097, June 2003
4. Kuo RL, Kim SC, Lingeman JE, Paterson RF, Watkins SL, Simmons GR, and Steele RE.  Holmium laser enucleation of the prostate (HoLEP):  the Methodist Hospital experience with >75 gram enucleations.  J Urol 170:149-152, July 2003
5. Kuo RL, Paterson RF, Siqueira Jr. TM, Watkins SL, Simmons GR, Steele RE, and Lingeman JE.  Holmium laser enucleation of the prostate:  morbidity in a series of 206 patients.  Urology 62:59-63, July 2003
6. Kuo RL, Paterson RF, Siqueira, Jr TM, Evan AP, McAteer JA, Williams, Jr JC, Lingeman JE.  In vitro assessment of ultrasonic lithotriptors.  J Urol 170:1101-1104, October 2003
7. Lingeman JE, Kim SC, Kuo RL, McAteer JA, and Evan AP.  Shockwave lithotripsy:  anecdotes and insights.  J Endourol 17(9):687-693, November 2003
8. Kuo RL, Lingeman JE, Evan AP, Paterson RF, Bledsoe SB, Kim SC, Munch LC, and Coe FL.  Endoscopic renal papillary biopsies:  a tissue retrieval technique for histological studies in patients with nephrolithiasis.  J Urol 170:2186-2189, December 2003
9. Kuo RL, Lingeman JE, Evan AP, Paterson RF, Parks JH, Bledsoe SB, Munch LC, and Coe FL.  Urine calcium and volume predict coverage of renal papilla by Randall’s plaque.  Kidney International, 64:2150-2154, December 2003
10. Shao Y, Connors BA, Evan AP, Willis LR, Lifshitz DA, and Lingeman JE.  Morphological changes induced in the pig kidney by extracorporeal shock wave lithotripsy:  nephron injury.  The Anatomical Record, Part A 275A:979-989, 2003
11. Connors BA, Evan AP, Willis LR, Simon JR, Fineberg NS, Lifshitz DA, Shalhav AL, Paterson RF, Kuo RL, and Lingeman JE.  Renal nerves mediate changes in contralateral renal blood flow after extracorporeal shock wave lithotripsy.  Nephron Physiology, 95:67-75, 2003
12. Kuo RL, Paterson RF, Siqueira TM Jr, Evan AP, McAteer JA, Williams JC Jr, and Lingeman JE.  In vitro assessment of the Lithoclast Ultra intracorporeal lithotriptor.  J Endourol 18(2):153-156, March 2004
13. Zarse CA, McAteer JA, Tann M, Sommer AJ, Kim SC, Paterson RF, Hatt EK, Lingeman JE, Evan AP, and Williams, Jr JC.  Helical CT accurately reports urinary stone composition using attenuation values:  in vitro verification using high resolution micro CT calibrated to FT-IR microspectroscopy.  Urology 63(5):828-833, May 2004
14. Parks JH, Worcester EM, Coe FL, Evan AP, and Lingeman JE.  Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones.  Kidney Intl 66(2):777-785, August 2004
15. Lingeman JE.  Editorial:  Stone treatments:  current trends and future possibilities.  J Urol 172(5 Pt 01):1774, November 2004
16. Zarse CA, McAteer JA, Sommer AJ, Kim SC, Hatt E, Lingeman JE, Evan AP, and Williams JC Jr.  Non-destructive analysis of urinary calculi using micro computed tomography.  BMC Urology 4(1):15, December 2004
17. Kim SC, Tinmouth WW, Kuo RL, Paterson RF, Lingeman JE.  Simultaneous holmium laser enucleation of prostate and upper-tract endourologic stone procedures.  J Endourol 18(10):971-975, December 2004
18. Williams JC Jr, Kim SC, Zarse CA, McAteer JA, Lingeman JE.  Progress in the use of helical CT for imaging urinary calculi.  J Endourol 18(10):937-941, December 2004
19. Kim SC, Coe FL, Tinmouth WW, Kuo RL, Paterson RF, Parks JH, Munch LC, Evan AP, Lingeman JE.  Stone formation is proportional to papillary surface coverage by Randall’s plaque.  J Urol 173(1):117-119, January 2005
20. Willis LR, Evan AP, Connors BA, Shao Y, Blomgren PM, Pratt JH, Fineberg NS, Lingeman JE.  Shockwave lithotripsy:  dose-related effects on renal structure, hemodynamics, and tubular function.  J Endourol 19(1):90-101, January/February 2005
21. Evan AP, Lingeman JE, Coe FL, Shao Y, Parks JH, Bledsoe SB, Phillips CL, Bonsib S, Worcester EM, Sommer AJ, Kim SC, Tinmouth WW, Grynpas M.  Crystal-associated nephropathy in patients with brushite nephrolithiasis.  Kidney Intl 67(2):576-591, February 2005
22. Kuo RL, Paterson RF, Siqueira TM Jr, Kim SC, Lingeman JE.  High-powered holmium ablation: a comparison of setting effectiveness using a tissue surrogate model.  J Endourol 19(2):239-241, March 2005
23. Kim SC, Tinmouth WW, Kuo RL, Paterson RF, Lingeman JE.  Using and choosing a nephrostomy tube after percutaneous nephrolithotomy for large or complex stone disease:  a treatment strategy.  J Endourol 19(3):348-352, April 2005
24. Kim SC, Kuo RL, Tinmouth WW, Watkins S, Lingeman JE.  Percutaneous nephrolithotomy for calyceal diverticular calculi:  a novel single-stage approach.  J Urol 173(4):1194-1198, April 2005
25. Paterson RF, Kim SC, Kuo RL, Lingeman JE, Evan AP, Connors BA, Williams JC Jr, McAteer JA.  Shock wave lithotripsy of stones implanted in the proximal ureter of the pig.  J Urol 173(4):1391-1394, April 2005
26. Evan AP, Coe FL, Rittling SR, Bledsoe SM, Shao Y, Lingeman JE, Worcester EM.  Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers:  osteopontin localization.  Kidney Intl 68(1):145-154, July 2005
27. Kim SC, Hatt EK, Lingeman JE, Nadler RB, McAteer JA, Williams JC Jr.  Cystine:  helical computerized tomography characterization of rough and smooth calculi in vitro.  J Urol 174(4 Pt 1):1468-1470, October 2005
28. Evan AP, Coe FL, Lingeman JE, Worcester E.  Insights on the pathology of kidney stone formation.  Urol Res 33(5):383-389, November 2005
29. Matlaga BR, Kim SC, Kuo RL, Watkins SL, Lingeman JE.  Holmium laser enucleation of the prostate for prostates of >125mL.  BJU International 97(1):81-84, January 2006
30. Kim SC, Ng JC, Matlaga BR, Lifshitz DA, Lingeman JE:  Use of lower pole nephrostomy drainage following endorenal surgery through an upper pole access.  J Urol 175(2):580-584, February 2006
31. Willis LR, Evan AP, Connors BA, Handa RK, Blomgren PM, Lingeman JE:  Prevention of lithotripsy-induced renal injury by pre-treating kidneys with low-energy shock waves.  J Am Soc Nephrol, 17(3):663-73, March 2006
32. Matlaga BR, Kim SC, Watkins SL, Kuo RL, Munch LC, Lingeman JE.  Percutaneous nephrolithotomy for ectopic kidneys:  over, around, or through.  Urology 67(3):513-517, March 2006
33. Matlaga BR, Kim SC, Watkins SL, Munch LC, Chan BW, Lingeman JE.  Pre-percutaneous nephrolithotomy opacification for calyceal diverticular calculi.  J Endourol 20(3):175-178, March 2006
34. Evan AP, Lingeman JE, Coe FL, Worcester E.  Randall’s plaque:  pathogenesis and role in calcium oxalate nephrolithiasis.  Kidney Intl 69(8):1313-1318, April 2006
35. Matlaga BR, Kim SC, Watkins SL, Kuo RL, Munch LC, Lingeman JE.  Changing composition of renal calculi in patients with neurogenic bladder.  J Urol 175(5):1716-1719, May 2006
36. Matlaga BR, Williams JC Jr, Kim SC, Kuo RL, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Munch LC, Lingeman JE.  Endoscopic evidence of calculus attachment to Randall’s plaque.  J Urol 175(5):1720-1724, May 2006
37. Miller NL and Lingeman JE.  Treatment of kidney stones:  current lithotripsy devices are proving less effective in some cases.  Nature Clinical Practice Urology 3(5):236-237, May 2006
38. Evan AP, Coe FL, Lingeman JE, Shao Y, Matlaga BR, Kim SC, Bledsoe SB, Sommer AJ, Grynpas M, Phillips CL, Worcester EM.  Renal crystal deposits and histopathology in patients with cystine stones.  Kidney Intl 69:2227-2235, June 2006
39. Connors BA, Evan AP, Blomgren PM, Willis LR, Handa RK, Lifshitz DA, Lingeman JE, Ying J.  Reducing shock number dramatically decreases lesion size in a juvenile kidney model.  J Endourol 20(9):607-611, September 2006
40. Williams JC Jr, Matlaga BR, Kim SC, Jackson ME, Sommer AJ, McAteer JA, Lingeman JE, Evan AP.  Calcium oxalate calculi found attached to the renal papilla:  preliminary evidence for early mechanisms in stone formation.  J Endourol 20(11):885-890, November 2006
41. Handa RK, Matlaga BR, Connors BA, Ying J, Paterson RF, Kuo RL, Kim SC, Lingeman JE, Evan AP, Willis LR.  Acute effects of percutaneous tract dilation on renal function and structure.  J Endourol 20(12):1030-1040, December 2006
42. Matlaga BR, Coe FL, Evan AP, Lingeman JE.  The role of Randall’s plaque in the pathogenesis of calcium stones.  J Urol 177:31-38, January 2007
43. Matlaga BR, Miller NL, Terry C, Kim SC, Kuo RL, Coe FL, Evan AP, Lingeman JE.  The pathogenesis of calyceal diverticular calculi.  Urol Res 35:35-40, February 2007
44. Kim SC, Matlaga BR, Tinmouth WW Kuo RL, Evan AP, McAteer JA, Williams JC Jr, Lingeman JE.  In vitro assessment of a novel dual probe ultrasonic intracorporeal lithotriptor.  J Urol, 177:1363-1365, April 2007
45. Miller NL, Matlaga BR, Lingeman JE.  Techniques for fluoroscopic percutaneous renal access.  J Urol, 178:15-23, July 2007
46. Handa RK, McAteer JA, Willis LR, Pishchalnikov YA, Connors BA, Ying J, Lingeman JE, Evan AP.  Dual-head lithotripsy in synchronous mode:  acute effect on renal function and morphology in the pig.  BJU Intl 99:1134-1142, 2007
47. Evan AP, McAteer JA, Connors BA, Lingeman JE.  Renal injury in SWL is significantly reduced by slowing the rate of shock wave lithotripsy.  BJU Intl 100:624-628,2007
48. Zarse CA, Hameed TA, Jackson ME, Pishchalnikov YA, Lingeman JE, McAteer JA, Williams JC Jr.  CT visible internal stone structure – but not Hounsfield unit value – of calcium oxalate monohydrate (COM) calculi predicts lithotripsy fragility in vitro.  Urol Res 35:201-206, 2007
49. Evan AP, Coe FL, Lingeman JE, Shao Y, Sommer AJ, Bledsoe SB, Anderson JC, Worcester EM.  Mechanism of formation of human calcium oxalate renal stones on Randall’s plaque.  The Anatomical Record 290:1315-1323, August 2007
50. Evan AP, McAteer JA, Connors BA, Blomgren PM, Lingeman JE.  Renal injury in SWL is significantly reduced by slowing the rate of shock wave lithotripsy.  BJU Intl 100:624-628, 2007
51. Evan AP, Bledsoe S, Worcester EM, Coe FL, Lingeman JE, Bergsland KJ.  Renal inter-α-trypsin inhibitor heavy chain 3 increases in calcium oxalate stone-forming patients.  Kidney Intl 72:1503-1511, September 2007
52. Kim SC, Burns EK, Lingeman JE, Paterson RF, McAteer JA, Williams JC, Jr.  Cystine calculi:  correlation of CT-visible structure, CT number, and stone morphology with fragmentation by shock wave lithotripsy.  Urol Res 35:319-324, October 2007
53. Evan AP, McAteer JA, Connors BA, Pishchalnikov YA, Handa RK, Blomgren P, Willis LR, Williams JC Jr, Lingeman JE, and Gao S.  Independent assessment of a wide-focus, low-pressure electromagnetic lithotripter:  absence of renal bioeffects in the pig.  BJU Intl, on-line article, October 2007
54. Humphreys MR, Miller NL, Lingeman JE.  Modified ureterosigmoidostomy (Mainz Pouch II):  a nonrefluxing stented vs. unstented laparoscopic porcine model.  BJU Intl 101:238-244, January 2008
55. Matlaga BR, McAteer JA, Connors BA, Handa RK, Evan AP, Williams JC Jr, Lingeman JE, Willis LR.  Potential for cavitation-mediated tissue damage in shockwave lithotripsy.  J Endourol 22(1):121-126, January 2008
56. Humphreys MR, Miller NL, Williams JC, Jr, Evan AP, Munch LC, Lingeman JE.  A new world revealed:  early experience with digital ureteroscopy.  J Urol 179:970-975, March 2008
57. Evan AP, Lingeman JE, Coe FL, Worcester EM.  Role of interstitial apatite plaque in the pathogenesis of the common calcium oxalate stone.  Seminars of Nephrology 28(2):111-119, March 2008
58. Matlaga BR, Kim SC, Lingeman JE.  Improving outcomes of percutaneous nephrolithotomy – access.  (In press:  EAU Update Series)

Application and 3 letters of recommendation are to be mailed to:

James E. Lingeman, M.D.
1801 North Senate Blvd., Suite 220
Indianapolis, IN  46202
Phone:  317/962-2485
FAX:  317/962-2893
E-mail:  jlingeman@clarian.org